Finest MLB Bets for Tuesday, September sixteenth: Prime Baseball Betting Picks Immediately


Sep 11, 2025; Chicago, Illinois, USA; Chicago White Sox shortstop Colson Montgomery (12) hits a two-RBI single in opposition to the Tampa Bay Rays in the course of the first inning at Fee Subject. Obligatory Credit score: Matt Marton-Imagn Photos

Pennant races are coming right down to the wire! As a Mets fan, that’s unlucky, however no less than it provides us extra video games the place we will anticipate groups to subject their greatest lineups. Let’s go!

Season File: 12-8-2, +3.95 Items

Cubs at Pirates

Choose: Pirates ML (-120 Fanatics)

We get an actual marquee pitching matchup right here. Cade Horton, the present betting favourite for the NL Rookie of the Yr, goes up in opposition to Paul Skenes, a digital lock to win NL Cy Younger.

It’s powerful to guess on the Pirates typically, however with Skenes on the mound they at all times have a great shot even with their regular popgun offense.

Skenes’ total greatness is after all no secret, however he’s extremely constant as nicely. He’s gone no less than 5 innings in all however 1 of his 30 begins, and he’s allowed greater than 2 earned runs simply 5 occasions.

The one actual danger right here is that he’s in an unannounced load administration slowdown. He went simply 5 IP, 16 batters, and 64 pitches in his begin final week in Baltimore. Then once more, which may have been a one-off incidence as he faces a contender tonight.

He has pitched 178 innings on the 12 months, after going a complete of 160 IP final season, so he’s on observe for a really regular 30 IP improve or so.

He faces a Cubs lineup that simply has not been that good recently as they’re slashing simply .236/.312/.390 because the All-Star break, and can play positively with out Kyle Tucker and fairly presumably with out Seiya Suzuki, who has missed the previous 4 video games with an undisclosed sickness.

Cade Horton has been terrific for the Cubs, however a lot better within the Pleasant Confines of Wrigley Subject (1.55 ERA, 0.96 WHIP) than on the street (3.75 ERA, 1.25 WHIP).

In the meantime, the Pirates really play considerably nicely within the land of the Three Rivers and scrumptious Primanti Sandwiches, going 42-34 on the season at dwelling with a 9.9% ROI as per VSiN.

Let’s roll with the Pirates and their ace right here.

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Orioles at White Sox

Choose: White Sox ML (-124 FanDuel)

It’s simple to dream on the way forward for these two groups — extra so the 2026 future for the Orioles and a bit additional out for the Sox. However I like how they’re every rolling out their promising younger bats.

As for at this time’s pitchers, Shane Smith made the All-Star sport for the White Sox, however then hit the IL. Since his return on August 1st he’s gone 3-0 with a 2.84 ERA and 0.95 WHIP, with a 23.6% Okay% and a considerably excessive 9.6% BB%.

He’s been good at dwelling all 12 months with a 2.98 ERA and 0.98 WHIP at regardless of the White Sox name their dwelling park now (Fee Subject apparently).

Orioles starter Dean Kremer is type of the definition of league common. He’s obtained a 4.43 ERA on the 12 months with a 1.26 WHIP and 20.1% Okay%. They’re all just about his profession ranges as nicely.

He’s had some forearm points and solely went 3 IP his final begin, which was 11 days in the past. In his two outings earlier than that he yielded 16 hits and 13 earned runs in simply 8 innings whole.

Unsure what we get out of Kremer tonight, and the Orioles’ depleted bullpen shouldn’t be suited to go any size.

The O’s do get Jordan Westburg again tonight, however nobody within the present lineup is hitting notably nicely recently.

I’ll go along with the White Sox.

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